Low-Dose Tamoxifen Feasible Option in Breast Cancer

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Low-Dose Tamoxifen Feasible Option in Breast Cancer

Сообщение goon2019 » 16 авг 2019, 00:14

Low-Dose Tamoxifen Feasible Option in Breast Cancer


A low-dose treatment of tamoxifen – 5 mg daily rather than the conventional 20 mg daily – appears to offer women protection against recurrence of early stage breast cancer and also reduces adverse events that often accompany tamoxifen cancer prevention therapy, researchers reported here.Nolvadex dosage
After a median follow-up of 5.1 years, women diagnosed with breast intraepithelial neoplasia who took 5 mg of tamoxifen for 3 years had 14 breast cancer events compared with 28 events among women in the study who were assigned to placebo (P=0.024), reported Andrea De Censi, MD, director of the medical oncology unit at the National Hospital E.O. Ospedali Galliera – S.C. Oncologia Medica in Genoa, Italy.
"Our phase III TAM-01 study shows that a lower dose of tamoxifen – 5 mg per day given for 3 years – decreases by 52% the risk of a recurrence in women with breast intraepithelial neoplasia – that is, ductal carcinoma in situ (DCIS), lobular carcinoma in situ, and atypical ductal hyperplasia," De Censi told MedPage Today at the annual San Antonio Breast Cancer Symposium.
The researchers also reported that tamoxifen appeared to be protective systemically. There were 12 breast cancer events in the contralateral breast among the placebo patients compared with three in the patients taking low-dose tamoxifen (P=0.018).
"I think our study is practice changing because we show a great effect that is similar to what was seen with the standard dose in previous trials, but with much lower adverse side effects," he said. "So the women with this disease can benefit from low-dose tamoxifen – either 10 mg every other day or by cutting the tablets in half, for a dose of 5 mg a day. The most important implication is among the women who are healthy but who may be at risk for breast cancer [that they] may benefit from a lower dose of tamoxifen."
The study conducted at 14 centers in Italy randomized 253 women to tamoxifen at 5 mg a day and 247 women to placebo. The women were approximately 54 years old; about 45% were premenopausal; 70% were diagnosed with DCIS; two-thirds were diagnosed with hormone-positive disease, while hormone receptor status was unknown for the other women. De Censi said most cases of breast intraepithelial neoplasia are hormone positive; about 84% of the women diagnosed with the disease opted to undergo conservative surgical therapy.
"Breast intraepithelial neoplasia significantly increases a woman's risk for invasive breast cancer," he said. "Because they are often driven by the hormone estrogen, treatment commonly includes 5 years of tamoxifen, given at 20 mg per day, after surgery and, if needed, radiotherapy.
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